a16z monthly newsletter - therapeutics, networks, and chasms

Andreessen Horowitz

a16z monthly newsletter - therapeutics, networks, and chasms
a16z
JANUARY 2019
1
with Amy Abernethy, Sonal Chokshi, James Collins, Jorge Conde, Susannah Fox, Christina Lopes, James L. Madara, Vas Narasimhan, Vijay Pande, Anil Sethi, Hanne Tidnam
It’s incredible that we find any medicines that work in the human body at all, given that we're the incredibly complex product of billions of years of evolution. Yet as we move from small molecules to large molecules to other modalities for making medicines -- and as technology comes in -- more is possible than ever before. From the evolution of the field of synthetic biology and the science (and business) of making medicines, to managing data and training doctors, this special healthcare series covers it all:
with Andrew Chen, Frank Chen, D'arcy Coolican, and Li Jin
The most successful companies and products of the internet era have all been predicated on the concept of network effects, but lately, reality seems to be diverging from theory. Does that mean network effects as we know them are dead? No! But in practice, they are more dynamic than ever -- evolving as product, users, competition, and even regulations change. So how do we know what we don't know, and what are the next opportunities here?
2
3
by Martin Casado
"Crossing the chasm" is a useful model for thinking about going from early adopters to majority use, but for many enterprise startups, the model doesn't always play out as founders expect. There's a lot of nuance to applying it in practice -- especially given the fast pace of innovation today and secular shifts such as open source, cloud, and bottom-up services. So how should founders think about all this, particularly when it comes to geographic expansion, incumbents, and more? 
by Chris Dixon 
Technologies -- from smartphones to cloud to video to the internet -- usually arrive in pairs: a "strong" form and a "weak" form. Strong technologies adapt the world to themselves, building from first principles; weak technologies, on the other hand, adapt to the world as it currently exists. Yet strong technologies are the ones that define new eras, and progress... Speaking of: As open source has grown in importance, who will control the software that powers the next generation of the internet? 
  • read this post on strong and weak technologies
  • read this article on how blockchains and cryptocurrencies can do for cloud-based services what open source did for software
4
5
with Frank Chen, Joel de la Garza, Benedict Evans, and Steven Sinofsky
Every year, CES puts the latest and greatest developments in consumer technology on display in Vegas. But beyond the excitement and the hype, what’s really here (or not here) to stay when it comes to the smart, connected home and voice interfaces? What's our pulse-check on the broader tech trends at play? And then, how should we think about the broader surface area for attacks... and other key trends for security in 2019?
This is the monthly edition of the a16z newsletter, which features content and resources curated and produced by Andreessen Horowitz. You can catch up on past newslettersupdate your preferences, or unsubscribe here

You are receiving this newsletter since you opted in earlier; if you would like to opt out of future newsletters, you can unsubscribe immediately. Also please note that the content here is for informational purposes only and does NOT constitute an offer or solicitation to purchase any investment or a recommendation to buy or sell a security. In fact, the content is not directed to any investor or potential investor and may not be used to evaluate or make any investment. For more details please see a16zcrypto.com/disclosures.
Andreessen Horowitz
© 2019 | Andreessen Horowitz 2865 Sand Hill Road, Suite 101 Menlo Park, CA 94025 USA







This email was sent to root@inbound.listboxer.com
why did I get this?    unsubscribe from this list    update subscription preferences
Andreessen Horowitz · 2865 Sand Hill Road, Suite 101 · Menlo Park, CA 94025 · USA